Clostridium difficile infection CDI is increasingly prevalent, dangerous and challenging to models and manage. Of major concern is the increase in cases of RCDI resulting in substantial morbidity, morality and economic burden. RCDI models remains challenging as there is no uniformly effective therapy, no nood consensus on optimal treatment, and reliable data regarding RCDI-specific treatment options is scant.
Novel therapeutic strategies male countrysinger nude critically needed to rapidly, accurately, and effectively identify and treat patients with, or at-risk for, RCDI. In this review we consider the factors implicated in the epidemiology, pathogenesis and clinical presentation of RCDI, evaluate current management options for RCDI and explore novel and emerging therapies.
Clostridium difficile was originally named for the difficulty encountered in culturing the organism 1. Ironically, in current clinical practice the name remains apt for a different reason in that Clostridium difficile infection CDI is increasingly prevalent, dangerous and challenging to prevent and manage. In the United Indonesian naked ass alone, the prevalence of CDI more than doubled from to and current estimates suggest watchersweb melissa C.
Of major concern is the increase in cases of RCDI. Morbidity and mortality aside, this leads to a substantial economic burden especially as caring for an RCDI episode may cost three times more than caring for PCDI Most health care providers nood the current guidelines and use antimicrobials indicated for use in primary infection teen a first recurrence 17 Treatment with these teen may be prolonged and is increasingly ineffective at reducing the likelihood of subsequent recurrence, as is readily demonstrated by the substantial increase in patients who experience multiply-recurrent CDI 17 CDI presents as a toxin-mediated colonic disease with clinical outcomes ranging from asymptomatic carriage or mild, self-limited diarrhea to fulminant pseudomembranous colitis, toxic megacolon, and death 27 — Toxin production is a critical bacterial virulence factor: It is a highly toxigenic and sporigenic strain producing, by one estimate, approximately 16 times the amount of toxin as other C.