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Author information: The human immunodeficiency virus HIV infectiousness of anal intercourse AI has not been systematically reviewed, despite its role driving HIV epidemics among men who have sex with men MSM and its potential contribution to heterosexual spread.

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Systematic review and meta-analysis of the literature on HIV-1 infectiousness through AI was conducted. PubMed was searched to September A total of 62, titles were searched; four publications reporting per-act and 12 reporting per-partner transmission estimates were included.

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Overall, random effects model summary estimates were 1. Our modelling demonstrated intercouse it would require unreasonably low numbers of AI HIV exposures per partnership to reconcile the summary per-act and per-partner estimates, suggesting considerable variability in AI infectiousness between college within partnerships over time.

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AI may substantially increase HIV transmission risk even if the infected partner is receiving HAART; however, predictions naked highly sensitive to infectiousness assumptions based on viral load.

Unprotected AI is a high-risk practice for HIV transmission, probably with substantial variation in infectiousness. The significant crystal girl pussy between infectiousness estimates means that pooled AI HIV transmission probabilities should be used with caution.

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