Dec Scientific Reports.
The patho-mechanism of somatic driver mutations in cancer usually involves transcription, but the proportion of model and wild-type alleles transcribed from DNA bianka RNA is largely unknown. Our analysis focusing on 11 genes harbouring recurring mutations demonstrated allelic imbalance AI in most patients.
While the effect size was small in general, GATA2 exhibited the largest allelic imbalance. Differential expression analysis of the genes with significant AI showed no significant differential gene and isoform expression for the mutated genes, between mutated and wild-type patients.
In conclusion, our analyses identified AI in nine out of eleven recurrently mutated genes. AI might be a common phenomenon preview AML which potentially contributes to leukaemogenesis. Download full-text.
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Loss of KDM6A confers drug resistance in acute you porn dump leukemia. Jun Leukemia. Acute myeloid leukemia AML is an aggressive hematologic neoplasm resulting from the malignant transformation of myeloid progenitors.